Decreased high-energy phosphate ratios in the myocardium of men with diabetes mellitus type I.
نویسندگان
چکیده
AIMS/HYPOTHESIS To investigate whether alterations in high-energy phosphates occur in the myocardium of persons with diabetes mellitus type I. Microvascular abnormalities and dysfunction via thickening of the basement membrane are known to occur in diabetic patients. Myocardial high-energy phosphates have been shown to be reduced by ischemia, and alterations of the cardiac metabolism are the primary consequence of myocardial ischemia. METHODS The present study involved 34 male patients (mean age 35.5 +/- 10.1) with diabetes mellitus type I and 35 healthy male volunteers (mean age 36 +/- 8.6) as age-matched controls. Phosphorus-31 magnetic resonance spectroscopic imaging of the heart was performed in all subjects using a 1.5-T whole-body magnetic resonance scanner. The ratios of phosphocreatine (PCr) to beta-adenosinetriphosphate (beta-ATP) were calculated. Moreover, echocardiographic evaluation and stress tests were performed in all individuals. RESULTS The myocardium of patients with diabetes mellitus type I showed significantly decreased ratios of PCr to beta-ATP compared with healthy controls in the left ventricle (1.90 +/- 0.4 vs. 2.15 +/- 0.3, p < 0.05). We found a moderate negative correlation between the ratio of PCr to beta-ATP in the left ventricle and both, the diastolic left ventricular function (E/A; r = -0.41) and the glycohemoglobin A1c (GHbA1c; r = -0.42). CONCLUSION This study demonstrates for the first time a decreased ratio of PCr to beta-ATP in the myocardium of persons with diabetes mellitus type I without a known history of coronary heart disease.
منابع مشابه
Effect of 4 Weeks of High Intensity Interval Training with Curcumin Supplementation on COL-I, COL- II, SMAD3 Gene Expression in the Myocardium of Obese Male Rats with Type 2 Diabetes
Introduction: The aim of this study was investigating the effect of 4 weeks of high intensity interval training with curcumin supplement on the gene expression of collagen I, II and SMAD/3 in the myocardium of male obese rats with type 2 diabetes. Methods: In this experimental study, 35 male diabetic rats were divided in to 5 groups of seven; normal control, diabetic control, curcumin+diabeti...
متن کاملP2: Epidemiology Study on Anxiety in Patient with Diabetes in Iran
The purpose of this survey was the study of the occurrence of anxiety and depression symptoms in patients with Type 2 diabetes mellitus with regard to sex and body mass index (BMI). 333 individuals with type 2 diabetes mellitus participated in the study. Their demographic and clinical features were examined. The self–completed questionnaire ΗADS was used for anxiety and depression level evaluat...
متن کاملSexual Dysfunction in Men with Type II Diabetes
Background: Diabetes mellitus (DM) is a chronic disease inducing short-term and long-term complications including sexual dysfunction (SD) which can consequently reduce patients’ quality of life. Given the limited literature on frequency of SD in men experiencing diabetes in northern Iran, the present study was conducted in the city of Sari in Mazandaran Province, with the aim of investigating S...
متن کاملThe Relationship Between Type 2 Diabetes Mellitus and Osteoporosis in Elderly People: a Cross-sectional Study
Diabetes mellitus (DM) and osteoporosis are common diseases and their prevalence increases with age. Several investigations have indicated that type 1 DM has a significant relationship with bone loss, whereas in type 2 diabetes, this relationship is controversial. Therefore, this study was conducted to determine the relationship between osteoporosis and type 2 DM in elderly people. This populat...
متن کاملبررسی سطح لیپیدها و لیپوپروتئینهای سرم خون در بیماران مبتلا به دیابت ملیتوس تیپ 2 با گرفتگی عروق کرونر STUDY OF SERUM LIPID AND LIPOPROTEIN LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS
ABSTRACT Coronary artery disease (CAD) is the leading cause of death among non-insulin dependant diabetic (NIDDM) Patients. One of risk factor for CAD in dyslipidemia. In regards to high prevalence of NIDDM and CAD among our people, in the present study, levels of lipids and lipoproteins in two groups of patients, CAD+/NIDDM+ group and CAD+/NIDDM- group, were evaluated and compared. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
دوره 4 4 شماره
صفحات -
تاریخ انتشار 2002